Can anyone help me out here? This Average Dumb Guy needs an very low level explanation or confirmation.
Pseudouridine is used in mRNA therapies to help stabilize the mRNA, as well as make it translate (produce") more Spike Protein in the transfected cell (the cell that the Nano Lipid Particle “NLP”has now entered).
My very basic understanding is that the process of reverse transcription”hijacks” the cell into making the Wuhan 1 Spike Protein “SP” on mass (soon to be Wuhan 1 & Omicron Spike in new boosters). The cell will actually make itself produce the full sequence of the SP on the surface of itself. There will be multitudes of SP protruding from each cell.
But now, the Killer T-CELLS in a functioning system should quickly pick up the cells that have been transfected, and mark them as being foreign ie. “not us”.
It is my understanding that the pseudouridine actually prevents the Killer T-CELLS from seeing the transfected cell as “ not us”. It this the case?
And if it is (or isn’t, and you can tell me what does stop the mechanism of identifying “not us”) then for how long will the transfected cell remain in a state of “invisibility” to the Immune System?
This is important to me and my want to understand and formulate my own ideas on the knock on effects of the Spike Protein in the body.
At some point the Immune System does recognize the Spike Protein. This is a given to the the manufacturing of IgG Abs. But if the transfected cell is “invisible” is the Immune System possibly only recognizing the S1 sub unit? If it saw the S2 base unit, it would kill the transfected cell, stopping spike production across the body.
But some research has shown that Spike Production can take place for a very long time.
So does the “invisibility” of the transfected cell wane over time? Or it is the S1 that is being picked up and causing the IgG Immune Response?
This is interesting as if it is just the S1 then the production of trillions of Spike over long periods of time is very real. And the S1 will also cleave off and circulate throughout the body for long periods of time.
We also need to specifically note that LNP crosses the Blood Brain Barrier and will transfect cells in the Brain, Brain-stem itself. And then do the very things that I have asked above.
So we will definitely have the case where lymphocytes, Killer T-cells and the like will be attacking any organ or area where S1 is present (S1 has an affinity to bind to ACE2).
The outcomes from this are very, very poor.
But what happens to S2 upon apoptosis? It has base pairs, and will these base pairs separate? Or will the full S2 just circulate freely across the body. And what damage will the S2 cause? I am led to understand that S2 is associated with TP53 gene suppression. Is this correct?
Is S1 or S2 responsible for the damage / genetic alteration to the Toll Like Receptors?
These are a starting point for my deeper understanding of the mechanisms of injury that are at play.
I see ZERO point in reading through any science papers that are driven by the narrative. As all of them do not take into account the circulation and impact of Spike sub units in the body. They also do not factor in the transfection that takes place across the body (involving the BBB, which when transfected, will cause a cascade of illness and deaths downstream. All of which will never be linked back to the mRNA Therapy by narrative following science).
Narrative driven research is ONLY looking for Abs creation (IgG which is pointless for a respiratory virus) and FULL Spike Protein in the blood itself (which will be highly unlikely).
So can anybody help me understand this more, or confirm what I have right or wrong?
I share my own research with normal everyday people, in an everyday language.
Science has failed to allow the “everyday person” to have any real insights into what is going on, so that they can see the RED FLAGS, and make an INFORMED DECISION to wait until more research has emerged on these experimental Therapies.
Here is a good explanation of the Pfizer mRNA vaccine. It could however be updated to say that we don't know yet whether the mRNA can be reverse transcribed into cellular DNA. Studies are being done on that with peer review.
https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/