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Bioanon's avatar

Nice article. I hate to rain on your parade about the gut membrane barrier, but I do have to raise some thoughts. For one, I'll say that the lipids do get to the large and small intestine of rats in the luciferase data. Secondly, and what has me more worried honestly, is the expulsion of bile into the gut. Bile already contains a few types of lipids (0.51% of total composition), and is produced by the liver, which we already know is heavily transfected by all LNP techs. If bile in the transfected liver gets viably coated mRNA put into it, then makes its way to the gallbladder, these particles could be expelled into the small intestine. Unfortunately for us, rats don't have gallbladders, so we also don't even have rat data on the transfection rate of that organ

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